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1

1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity

Robin D. Clark, Nicholas C. Ray, Karen Williams, Paul Blaney, Stuart Ward, Peter H. Crackett, Christopher Hurley, Hazel J. Dyke, David E. Clark, Peter Lockey, Rene Devos, Melanie Wong, Soraya S. Porre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 154 KB

english, 2008

2

Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase

Sharon A. Jackson, Sukhveen Sahni, Lan Lee, Yongyi Luo, Thaddeus R. Nieduzak, Guyan Liang, Yulin Chiang, Nicola Collar, David Fink, Wei He, Abdelazize Laoui, Jean Merrill, Ray Boffey, Peter Crackett,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 340 KB

english, 2005

3

Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators

Nicholas C. Ray, Robin D. Clark, David E. Clark, Karen Williams, H.G. Hickin, Peter H. Crackett, Hazel J. Dyke, Peter M. Lockey, Melanie Wong, René Devos, Anne White, Joseph K. Belanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 149 KB

english, 2007

4

Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Steve Price, Walter Bordogna, Richard J. Bull, David E. Clark, Peter H. Crackett, Hazel J. Dyke, Matthew Gill, Neil V. Harris, Julia Gorski, Julia Lloyd, Peter M. Lockey, Julia Mullett, Alan G. Roach,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 168 KB

english, 2007

5

2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists

Robin D. Clark, Nicholas C. Ray, Paul Blaney, Peter H. Crackett, Christopher Hurley, Karen Williams, Hazel J. Dyke, David E. Clark, Peter M. Lockey, Rene Devos, Melanie Wong, Anne White, Joseph K. Bel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 159 KB

english, 2007

6

Complexes of imidazoline (1,3H)-2-thione with Co(II) and Zn(II) salts

Eric S. Raper, Peter H. Crackett

Journal:

Inorganica Chimica Acta

Year:

1981

Language:

english

File:

PDF, 605 KB

english, 1981

7

A convenient synthesis of bisindolylmaleimides

Rino A. Bit, Peter H. Crackett, William Harris, Christopher H. Hill

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 205 KB

english, 1993

8

Synthesis of 2-(methoxycarbonyl)methyl-7-phenylacetamido-3-thiacepham-4-carboxylates

Peter H. Crackett, Colin V. Greengrass, Richard J. Stoodley

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 164 KB

english, 1986

9

Some observations regarding β-lactam-cleavage reactions of penicillanate 1,1-dioxides and related compounds

Peter H. Crackett, Richard J. Stoodley

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 164 KB

english, 1984

10

Asymmetric synthesis via acetal templates. 9. Further studies of the allylation reaction. Preparation of (−)-dihydromyoporone

William S. Johnson, Peter H. Crackett, John D. Elliott, Jacek J. Jagodzinski, Stephen D. Lindell, S. Natarajan

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 283 KB

english, 1984

11

Studies toward the Large-Scale Synthesis of the HIV Proteinase Inhibitor Ro 31-8959

Parkes, Kevin E. B., Bushnell, David J., Crackett, Peter H., Dunsdon, Stephen J., Freeman, Andrew C., Gunn, Michelle P., Hopkins, Richard A., Lambert, Robert W., Martin, Joseph A.

Journal:

Journal of Organic Chemistry

Year:

1994

Language:

english

File:

PDF, 1.25 MB

english, 1994

12

Identification of C -2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Zak, Mark, Hurley, Christopher A., Ward, Stuart I., Bergeron, Philippe, Barrett, Kathy, Balazs, Mercedesz, Blair, Wade S., Bull, Richard, Chakravarty, Paroma, Chang, Christine, Crackett, Peter, Deshmu

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 4.02 MB

english, 2013

13

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Hurley, Christopher A., Blair, Wade S., Bull, Richard J., Chang, Christine, Crackett, Peter H., Deshmukh, Gauri, Dyke, Hazel J., Fong, Rina, Ghilardi, Nico, Gibbons, Paul, Hewitt, Peter R., Johnson, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.23 MB

english, 2013

14

Total synthesis of analogues of the ?-lactam antibiotics. Part 5. 3-Thiacepham-4-exo-carboxylates and their 1,1,3,3-tetraoxides

Beagley, Brian, Crackett, Peter H., Pritchard, Robin G., Stoodley, Richard J., Greengrass, Colin W.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1990

Language:

english

File:

PDF, 1.31 MB

english, 1990

15

Total synthesis of analogues of the ?-lactam antibiotics. Part 6. (6R*)-4(t-butoxycarbonyl)-2-methoxycarbonyl-3-oxacepham 1,1-dioxides

Crackett, Peter H., Sayer, Paul, Stoodley, Richard J., Greengrass, Colin W.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1991

Language:

english

File:

PDF, 1.42 MB

english, 1991

16

Synthesis of racemic 3-thiacepham-4-carboxylates and their 1,1,3,3-tetroxides

Crackett, Peter H., Greengrass, Colin W., Stoodley, Richard J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1983

Language:

english

File:

PDF, 189 KB

english, 1983

17

?-Lactam-cleavage reactions of isopenam-3-carboxylates and their 2,2-dioxides

Crackett, Peter H., Pant, Chandra M., Stoodley, Richard J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1983

Language:

english

File:

PDF, 206 KB

english, 1983

18

Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

Gazzard, Lewis, Williams, Karen, Chen, Huifen, Axford, Lorraine, Blackwood, Elizabeth, Burton, Brenda, Chapman, Kerry, Crackett, Peter, Drobnick, Joy, Ellwood, Charles, Epler, Jennifer, Flagella, Mich

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.74 MB

english, 2015

19

HIV Protease Inhibitor Part 1: Use of Evans’ Oxazolidinone in Intermolecular Diels-Alder Reaction en route to 3,4-Substituted Cyclohexanones

Crackett, Peter, Demont, Emmanuel, Eatherton, Andrew, Frampton, Christopher S., Gilbert, Jenny, Kahn, Irfan, Redshaw, Sally, Watson, William

Journal:

Year:

2004

Language:

english

File:

PDF, 91 KB

english, 2004

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